The Developing Human Connectome Project has created a large open science resource which provides researchers with data for investigating typical and atypical brain development across the perinatal period.It has collected 1228 multimodal magnetic resonance imaging (MRI) brain datasets from 1173 fetal and/or neonatal participants, together with colla
PURPOSE:This study aimed to evaluate the safety, tolerability and pharmacokinetics of the combination of oral vinorelbine with erlotinib using the conventional (CSV) and metronomic (MSV) dosing schedules in patients with advanced non-small cell lung cancer (NSCLC).METHODS:This was an open-label, multiple dose-escalation phase I study.An alternating
BackgroundDespite strong evidence of clinical benefit, cardiac rehabilitation (CR) programs are currently underutilized and smartphone-based CR strategies are thought to address this unmet need.However, data regarding the detailed process of development are scarce.ObjectiveThis study focused on the development of a smartphone-based, patient-specifi
BackgroundHepatocellular carcinoma is a pathological type of liver cancer and accounts for the majority of primary liver cancers.We conducted a meta-analysis to evaluate the efficacy and safety of C immune checkpoint inhibitors in combination with antiangiogenic drugs in the treatment of hepatocellular carcinoma.MethodsWe searched scientific litera
The organic Rankine cycle (ORC) has been demonstrated to be an effective method for converting low-grade heat energy into electricity.This paper proposes an improved analysis method for the ORC system.A coupling model of the ORC system with a radial-inflow turbine efficiency prediction model is presented.Multi-objective optimization was conducted f